Our laboratory focuses on understanding the mechanistic changes associated with temporal lobe epilepsy with a specific interest in the role played by voltage gated sodium (Na) channels. Our studies correlate the changes in Na channel activity and isoform expression patterns with increased excitability of hippocampal and entorhinal cortex (EC) neurons and the subsequent changes in the global network circuit of the limbic system. We use a variety of techniques in our investigation including electrophysiology, immunohistochemistry, western blotting and single cell rtPCR.